一个计算机程序,用于评估在儿童肠壁的超高频超声波图像中基因解剖形态学:发展和观察者间的变化
Tobias Erlöv1, Tebin Hawez2, Christina Granéli2,3
1Department of Biomedical Engineering, Faculty of Engineering, Lund University, 22363 Lund, Sweden.
Diagnostics (Basel, Switzerland)
|September 9, 2023
概括
一个新的计算机程序使用超高频超声波 (UHFUS) 图像准确测量肠壁厚度和振幅. 这种工具增强了对体内生理学差异的客观评估,有助于诊断像Hirschsprungsprung这样的疾病.
科学领域:
- 医疗成像医学成像
- 生物医学工程 生物医学工程
- 儿科手术 儿科手术
背景情况:
- 超高频超声波 (UHFUS) 显示出在基于基因结构差异的基础上,可以区分角质性和角质性肠壁.
- 以前的研究已经确定了肠壁组织解剖学和UHFUS发现之间的相关性.
研究的目的:
- 开发一款计算机程序,用于精确客观地评估肠壁的UHFUS图像中的组织解剖形态学.
- 为了能够自动计算不同肠壁层内的厚度和幅度.
主要方法:
- 与儿科外科医生和生物医学工程师合作开发一个易于使用的UHFUS图像分析计算机程序.
- 输入了23名患有直垂体细分肠病的儿童的体外肠壁图像.
- 通过程序计算厚度和振幅,由两个观察员进行评估,以评估观察者之间的变化.
主要成果:
- 观察者之间达成了很好的共识,类内相关系数在0.970到0.998.99之间.
- 布兰德-阿尔特曼图表显示测量的差异最小且一致.
- 厚度和幅度的平均差异很小,代表了整体平均值的低百分比 (厚度为1.1-3.6%,幅度为0.0-0.8%).
结论:
- 开发的计算机程序提供客观的,准确的,和时间效率的测量肠壁从UHFUS图像的体系学参数.
- 这种工具有可能加速对各种肠壁疾病的UHFUS诊断的研究.
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