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用于预测胃癌个性化免疫疗法反应的生物标志物
Moonsik Kim1,2, Ji Yun Jeong1,2, An Na Seo1,2
1Department of Pathology, School of Medicine, Kyungpook National University, 136-gil 90, Chilgokjungang-daero, Buk-gu, Daegu 41405, Republic of Korea.
Diagnostics (Basel, Switzerland)
|September 9, 2023
概括
胃癌 (GC) 免疫疗法显示出希望,但耐药性是一个挑战. 本综述探讨了PD-L1等生物标志物,以预测GC患者的免疫检查点抑制剂 (ICI) 反应.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 胃癌 (GC) 仍然是全球癌症死亡的主要原因.
- 分子异质性和获得的耐药性阻碍了针对GC的向治疗方法.
- 免疫疗法,特别是免疫检查点抑制剂 (ICI),为GC治疗提供了新的希望.
研究的目的:
- 审查胃癌中ICI反应的预测生物标志物.
- 专注于编程细胞死亡蛋白1 (PD-1) /编程死亡配体1 (PD-L1) 轴和其他生物标志物.
- 帮助选择GC患者的最佳治疗策略.
主要方法:
- 在GC治疗ICI当前预测生物标志物的文献综述.
- 生物标志物的分析,包括PD-L1,微卫星不稳定性,爱斯坦-巴尔病毒和瘤突变负担.
- 讨论潜在的新生物标志物和反应机制.
主要成果:
- 一些生物标志物,包括PD-L1表达,微卫星不稳定性,爱斯坦-巴尔病毒和瘤突变负担,影响GC中的ICI治疗反应.
- PD-L1表达是预测ICI疗效的关键焦点.
- 新兴的生物标志物和机制也在被调查.
结论:
- 准确的生物标志物识别对于GC中有效的ICI治疗至关重要.
- 了解这些生物标志物可以指导治疗选择并改善患者的治疗结果.
- 对新型生物标志物的进一步研究将增强针对GC的个性化医学方法.
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