希腊多发性硬化症患者的COVID-19疫苗接种和疾病过程
Christos Bakirtzis1, Natalia Konstantinidou1, Sotiria Stavropoulou De Lorenzo1
1Multiple Sclerosis Center, Second Department of Neurology, School of Medicine, Aristotle University of Thessaloniki, 54621 Thessaloniki, Greece.
Journal of clinical medicine
|September 9, 2023
概括
多发性硬化症 (PwMS) 患者的COVID-19结果显示,接种疫苗显著降低了住院风险. 然而,疫苗接种在疫情期间并没有显著影响这一脆弱人群的死亡率.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 随着COVID-19的爆发,全球出现了健康危机.
- 最初的担忧是,患有多发性硬化症 (MS) 等慢性疾病的人面临更高的风险.
- 了解MS (PwMS) 患者的COVID-19结果对于在流行病期间管理慢性疾病至关重要.
研究的目的:
- 为了评估希腊PwMS的COVID-19疾病过程.
- 探索疫苗接种对PwMS中SARS-CoV-2感染结果的影响.
主要方法:
- 全国匿名化行政记录的回顾性分析 (2020年2月至2021年12月).
- 识别与SARS-CoV-2感染的PwMS,收集人口统计,感染和疫苗接种数据.
- 研究样本:2351名PwMS (65.1%为女性,51.2%在感染时未接种疫苗).
主要成果:
- 260名PwMS在医院住院,25人死于COVID-19.这些人中,有260名PwMS在医院住院.
- 老年,男性性别和并发症独立增加了住院的风险.
- 修改疾病的治疗方法降低了住院的风险; 疫苗接种显著地防止了住院.
- 年龄是死亡率的唯一重要因素;疫苗接种对死亡率没有显著影响.
结论:
- 接种疫苗显著降低了感染SARS-CoV-2的PwMS住院的风险.
- 虽然年龄是一个重要的死亡风险因素,但疫苗接种对PwMS死亡率的影响需要进一步调查.
- 修改疾病的治疗方法可以在PwMS中提供保护性益处,防止住院治疗.
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