喘儿童和青少年的维持治疗:埃米利亚-罗马尼亚喘研究小组 (ERA) 的指导方针和建议
Valentina Fainardi1, Carlo Caffarelli1, Michela Deolmi1
1Pediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Journal of clinical medicine
|September 9, 2023
概括
儿童喘管理需要根据严重程度,表型和个人因素制定个性化治疗计划. 针对幼儿的量身定制疗法还需要进一步的研究,因为目前的指导方针往往是从成人研究中推断出来的.
科学领域:
- 儿科肺病学 儿科肺病学
- 临床实践指南 临床实践指南
- 基于证据的医学基于证据的医学.
背景情况:
- 喘是主要的慢性儿童疾病,全球影响高达20%.
- 目前的儿科喘维持治疗指南提供了多种方法和阶段.
- 需要更新关于儿童喘治疗的证据综合.
研究的目的:
- 总结关于儿童喘维持治疗的最新证据.
- 解决关于儿童和青少年喘治疗的关键临床问题.
- 为儿童喘管理制定专家驱动的建议.
主要方法:
- 一个多学科专家小组解决了10个临床问题.
- 搜索包括电子数据库和过去25年的灰色文学.
- 使用推,评估,开发和评估 (GRADE) 评级方法制定的建议.
主要成果:
- 药物选择受喘严重程度,表型,年龄和个体患者因素的影响.
- 有效控制喘需要识别并发症和可修改的风险因素.
- 儿童喘被认为是一种异质的疾病,具有可变的进展.
结论:
- 儿童喘治疗需要一种超出一般指导方针的个性化方法.
- 目前的儿科喘建议往往依赖于来自成人的数据.
- 在喘管理方面,急需开展儿科专用临床试验.
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