2型糖尿病的萨尔科佩尼亚:涉及可修改风险因素的研究
Surapaneni Lakshmi Sravya1, Jayshree Swain1, Abhay Kumar Sahoo1
1Department of Endocrinology, IMS & SUM Hospital, Bhubaneswar 751003, India.
Journal of clinical medicine
|September 9, 2023
概括
2型糖尿病患者有较高的麻症患病率. 低BMI,体力活动,血清,高血压和神经病变是这种人群中肉类症的关键预测因素.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 萨科佩尼亚因其对发病率的贡献而越来越受认可.
- 萨尔科佩尼亚和2型糖尿病 (T2DM) 之间存在显著的关联.
- 有限的数据可用于T2DM个体的肉类的患病率和预测因子.
研究的目的:
- 为了确定T2DM个体中肉类的患病率.
- 在T2DM人群中识别肉类的预测因子.
主要方法:
- 一项涉及159名T2DM患者 (病例) 和79名50岁以上的非糖尿病对照者的比较研究.
- 根据亚洲Sarcopenia2019工作组的标准进行了萨尔科佩尼亚评估,包括手握力,肌肉质量 (DXA) 和步行速度.
- 多变量回归分析以确定显著的预测因子,考虑人口统计,人体测量和生物化学参数 (包括HbA1c,葡萄糖,脂质,,肝脏,甲状腺功能,,维生素D,PTH).
主要成果:
- 与对照组 (8.86%,p=0.012) 相比,T2DM病例中的麻症患病率明显高 (22.5%).
- 多变量分析确定了低体重指数 (BMI),低体力活动,低血清,高血压和神经病变作为萨科佩尼亚的显著预测因素.
- 对于每个预测因素,报告了特定的几率比率 (OR) 和置信区间 (CI).
结论:
- 患有T2DM的个体表现出对萨科佩尼亚的敏感性增加.
- 在T2DM中发生肉类的关键可改变的危险因素包括低BMI,减少体力活动,高血压,神经病变和低血清.
- 针对这些风险因素为老年T2DM患者的肉症预防提供了潜在的策略.
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