血清25-氧维生素D水平与COVID-19的严重程度有关吗? 一个回顾性研究
Munachimso Kizito Mbata1,2, Mireille Hunziker1,3, Anja Makhdoomi1
1Cantonal Hospital Baselland, University Center of Internal Medicine, Rheinstrasse 26, 4410 Liestal, Switzerland.
Journal of clinical medicine
|September 9, 2023
概括
这项研究发现,住院患者的维生素D水平和COVID-19严重程度之间没有联系. 维生素D缺乏是常见的,但在这个大规模的2年观察性研究中与疾病进展无关.
科学领域:
- * 传染病 传染病
- * 内分泌学 在内分泌学.
- * * 公共卫生 公共卫生
背景情况:
- * 严重急性呼吸系统综合征 冠状病毒2 (SARS-COV2) 感染具有广泛的临床谱,从无症状病例到急性呼吸系统应急综合征 (ARDS) 严重的COVID-19.
- *在ARDS患者中经常观察到维生素D缺乏,但其在COVID-19病原和严重性中的具体作用尚不清楚.
- *了解像维生素D状况这样的潜在贡献因素对于管理COVID-19患者的结果至关重要.
研究的目的:
- * 调查血清25-基维生素D水平与住院患者COVID-19临床严重程度之间的关联.
- * 为了确定维生素D缺乏是否是更严重的COVID-19结果的危险因素.
- * 提供大量COVID-19患者群体中维生素D状态的数据.
主要方法:
- *回顾性观察性研究分析了763名住院COVID-19患者 (2020-2021) 的数据.
- *纳入标准要求在入院30天内对血清25-基维生素D进行评估.
- *维生素D缺乏症定义为血清水平<50nmol/L (<20ng/mL);主要结局是COVID-19的严重程度.
主要成果:
- *血清中位25-基维生素D水平为54nmol/L,其中47%的患者表现出维生素D缺乏.
- * 在维生素D缺乏和没有缺乏的患者组之间没有观察到COVID-19严重程度的显著差异 (81%vs84%轻度至中度病例,p=0.829).
- *大多数患者经历了轻度至中度的COVID-19,无论他们的维生素D状况如何.
结论:
- *这项大规模的观察性研究发现血清25-氧维生素D水平与COVID-19严重程度之间没有统计学上显著的关联.
- * 维生素D缺乏在住院COVID-19患者中很普遍,但似乎不能预测疾病的严重程度.
- *可能需要进一步的研究来探索影响COVID-19临床结果的其他因素.
相关概念视频
Role of Skin in Vitamin D Synthesis
5.3K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.3K
Connective Tissue Cell Types
3.3K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.3K
Role of Vitamins in Maintaining Bone Health
3.4K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.4K
Vitamins
772
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
772
Correlation
11.8K
In statistics, two variables are said to be correlated if the values of one variable are associated with the other variable. Depending on the relationship between two variables, correlation can be of three types– positive correlation, negative correlation, and zero correlation.
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
11.8K
Pulmonary Tuberculosis I
262
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
262


