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末期病患者下肢截肢的危险因素:全国性队列研究
Min Jun Seo1, Dong Geon Lee1, Se Yun Ko2
1Department of Plastic Surgery, Yonsei University Wonju College of Medicine, Wonju 26426, Republic of Korea.
Journal of clinical medicine
|September 9, 2023
概括
末期病 (ESKD) 患者面临较高的下肢截肢 (LEA) 风险. 关键的危险因素包括年龄,男性性别,糖尿病和透析,强调需要密切监测和考虑移植.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血管外科 血管外科
- 公共卫生 公共卫生
背景情况:
- 透析的末期脏病 (ESKD) 患者极易患脚和下肢截肢 (LEA).
- 低成本医疗系统显著影响患者的生活质量,并增加医疗保健支出.
- 在ESKD中识别LEA风险因素对于预测和预防至关重要.
研究的目的:
- 在末期病 (ESKD) 患者中确定与下肢截肢 (LEA) 相关的危险因素.
- 预测LEA的进展,并为ESKD患者提供预防策略.
主要方法:
- 利用了来自韩国国家健康保险服务 (KNHIS) 的18年 (2002-2019) 的数据.
- 分析了220,838名ESKD患者接受脏替代疗法 (RRT) 的数据,不包括创伤/毒素相关的截肢.
- 患有LEA (6348名患者) 和没有LEA (214,490名患者) 的组之间的风险因素比较.
主要成果:
- 在ESKD队列中,LEA的整体发病率为2.9%.
- 对LEA的显著风险因素包括年龄较大,男性性别,收入较低,非大都市居住,糖尿病和透析治疗.
- 周围血管疾病,微血管疾病和内血管程序/手术也与LEA风险增加有关.
结论:
- 患有ESKD的个人,特别是那些具有已识别的风险因素的人,需要对LEA进行警监测.
- 移植应该被视为一种潜在的预防措施,以预防ESKD患者的LEA.
- 了解这些风险因素可以指导有针对性的干预措施,以减少LEA的发生率并改善ESKD患者的结果.
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