相关实验视频

Updated: Sep 26, 2026

Using Retinal Imaging to Study Dementia

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

APOE ε4基因携带者在无症状的老年人中显示了视网膜毛细血管密度的降低

Ziyi Zhang¹, William Robert Kwapong¹, Le Cao¹

¹Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China.

Journal of clinical medicine

|September 9, 2023

概括

阿波蛋白E (APOE) ε4载体显示了视网膜微血管的减少,特别是在认知障碍时. 这表明视网膜成像可能有助于研究阿尔茨海默病的微血管贡献.

科学领域:

眼科医生眼科眼科
神经学神经学
遗传学遗传学是一种遗传学.

背景情况:

阿尔茨海默病 (AD) 与微血管病理有关.
早期识别与Apolipoprotein E (APOE) 相关的微血管变化对于理解AD和开发干预措施至关重要.

研究的目的:

在无症状的老年人中调查APOE ε4载体和非载体之间的视网膜微血管结构的差异.
探索APOE ε4状态,认知功能和视网膜微血管参数之间的关联.

主要方法:

对163名无症状的老年人 (≥55岁) 进行了APOE ε4基因型分析,神经心理测试 (MoCA) 和光相干断层扫描血管造影 (OCTA).
参与者被分为认知障碍 (CI) 或非认知障碍 (NCI).

主要成果:

与非载体相比,APOE ε4载体表现出较低的表面血管密度 (SVC) (p=0.023).
与NCI参与者相比,CI参与者显示SVC密度降低 (p=0.006).
在CI组中,与非载体相比,APOE ε4载体显著降低了SVC (p=0.006) 和深血管密度 (DVC,p=0.048).

结论:

认知障碍和APOE ε4基因型在老年人中显著影响视网膜微血管.
视网膜微血管测量可以作为大脑微循环的潜在生物标志物,有助于AD研究.

关键词:

在APOE基因型中,APOE基因型阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.认知认知认知光学连贯性断层扫描血管图谱视网膜微血管学

更多相关视频

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Published on: March 12, 2022

Author Spotlight: Improved Lipofuscin Models and Quantification of Outer Segment Phagocytosis Capacity in Highly Polarized Human Retinal Pigment Epithelial Cultures

Author Spotlight: Improved Lipofuscin Models and Quantification of Outer Segment Phagocytosis Capacity in Highly Polarized Human Retinal Pigment Epithelial Cultures

Published on: April 14, 2023

相关概念视频

Alzheimer Disease l: Introduction

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...