相关实验视频

Updated: Jul 16, 2025

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Published on: January 26, 2013

9600个胚胎的分裂模式:不规则的分裂的重要性

Maya Shavit^1,2, Daniel Gonen², Yuval Atzmon^1,2

¹IVF Unit, Department of Obstetrics and Gynecology, Hillel-Yaffe Medical Center, Hadera 3810000, Israel.

Journal of clinical medicine

|September 9, 2023

概括

人类胚胎的不规则裂解 (IRC),在17.5%的病例中观察到,与男性因素有关,并影响了试管婴儿的成功. 早期或多次IRC事件会降低新生周期中的爆发和活产率.

科学领域:

生殖医学生殖医学
胚胎学胚胎学
在体外受精 (IVF)

背景情况:

不规则裂变 (IRC) 是人类胚胎发育过程中观察到的现象.
了解IRC对体外受精 (IVF) 结果的影响对于改善治疗成功至关重要.

研究的目的:

调查人类胚胎中不规则裂解 (IRC) 的发生率.
评估IRC与各种患者和治疗特征之间的关联.
确定IRC对试管婴儿治疗结果的影响,包括怀孕和活产率.

主要方法:

一项前性观察性研究,涉及1001名妇女和1976名辅助生殖治疗.
对胚胎形态动力学进行分析,以识别和量化IRC事件.
统计评估IRC与患者人口统计,治疗变量和生殖结果之间的相关性.

主要成果:

IRC的发病率为17.5%,其中35%发生在第一个细胞周期中.
IRC与男性因子不育 (p=0.01) 和更高的细胞体内精子注射 (ICSI) 率 (p=0.01) 相相关.
早期或多次IRC事件的胚胎显示爆发率降低 (p=0.01),新周期临床怀孕率降低 (p=0.01),活产率降低 (p=0.04).

结论:

不规则切割事件的时间和数量是人类胚胎发育潜力的重要指标.
IRC对关键的试管婴儿成功指标产生负面影响,特别是在新鲜胚胎移植周期中.
使用囊胚细胞的冷胚胎移植周期显示了与IRC存在无关的可比结果.

关键词:

临床怀孕率临床怀孕率直接的切割直接的切割不规则的裂口不规则的裂口活生生的出生率是多少形态动力学形态动力学时间延迟成像技术的时间延迟成像.

更多相关视频

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Published on: February 22, 2016

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

Published on: September 7, 2021

相关概念视频

Cleavage and Blastulation

Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.

Nondisjunction

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...