同时冠状动脉疾病在同卵双胞胎:病例报告和系统文献审查
Odysseas Kamzolas1, Andreas S Papazoglou2, Eleftherios Gemousakakis1
1401 General Military Hospital of Athens, 11525 Athens, Greece.
Journal of clinical medicine
|September 9, 2023
概括
一卵双胞胎经常同时发展出冠状动脉疾病 (CAD) 和急性冠状动脉综合征 (ACS). 这篇综述强调了单胞胎双胞胎在CAD呈现和解剖学上的高度一致性,这表明了共同的遗传和环境影响.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 冠状动脉疾病 (CAD) 是一种复杂的疾病,受遗传,表观遗传和环境因素的影响.
- 在同卵双胞胎中观察到一致的CAD发育,表明潜在的遗传倾向.
- 一卵性双胞胎中急性冠状动脉综合征 (ACS) 需要进一步调查共享的风险因素.
研究的目的:
- 系统地审查和分析单胞胎双胞胎同时出现CAD的病例报告.
- 评估冠状动脉解剖学和临床表现在受影响的双胞胎对中的一致性.
- 探索遗传因素在同卵双胞胎中CAD同时发展中的作用.
主要方法:
- 对PubMed,科学网络和Scopus数据库的系统文献审查 (直到2023年2月28日).
- 包括病例报告和病例系列,详细介绍单胞胎双胞胎同时发生的CAD.
- 对临床表现,冠状动脉解剖学和遗传发现的分析.
主要成果:
- 确定了31对单胞胎双胞胎,同时患有CAD和ACS,平均年龄为45±12岁 (81%的男性).
- 在双胞胎对中观察到冠状动脉解剖 (79%) 和病变部位 (77%) 的高度一致性.
- 基因查在6对双胞胎中发现了5种CAD相关的基因多态性.
结论:
- 一卵双胞胎在冠状动脉解剖学和CAD的临床表现方面具有很高的一致性.
- 共同的遗传因素和环境影响可能有助于同卵双胞胎同时发展CAD.
- 未来的双胞胎研究可以阐明CAD的遗传性,并解开遗传,表观遗传和环境贡献.
相关概念视频
Case Studies
11.7K
There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
11.7K
Coronary Artery Disease I: Introduction
20
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
20
Coronary Artery Disease V: Interprofessional Care
9
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
9
Coronary Artery Disease II: Pathophysiology
12
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
12
Acute Coronary Syndrome III: Diagnostic Studies
9
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
9
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
13
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
13


