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在祖先基因组特征拉丁裔患者的三阴性乳腺癌中放松的miRNA表达

Maram Almohaywi¹, Bruna M Sugita², Ariana Centa²

¹Microbiology Department, Howard University Cancer Center, Howard University, Washington, DC 20059, USA.

International journal of molecular sciences

|September 9, 2023

概括

这项研究揭示了与拉丁裔患者三阴性乳腺癌 (TNBC) 副本数量变化相关的特定微RNA (miRNA) 变化. 这些miRNA配置文件提供了TNBC攻击性和患者祖先影响的见解.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
分子生物学分子生物学

背景情况:

三重阴性乳腺癌 (TNBC) 可以表现出与微RNA (miRNA) 放松调节相关的侵略性表型.
关于西班牙裔和拉丁美洲妇女TNBC分子概况的数据有限.
瘤分子特征可能因种族和种族而异.

研究的目的:

调查拉丁裔患者TNBC中的全基因组拷贝数变化 (CNA) 和全球miRNA表达.
在这个群体中识别与CNA相关的特定miRNA.
探索与TNBC进展和结果相关的已识别的miRNAs的临床相关性.

主要方法:

在28名拉丁裔妇女中,同时对全基因组CNA和miRNA表达的TNBC活检进行分析.
在瘤和相邻的非瘤组织中验证了四种选择的miRNAs (miR-141-3p,miR-150-5p,miR-182-5p,miR-661).
对CNA和miRNA数据的综合分析.

主要成果:

一个由28个与CNA相关的miRNA组成的小组被确定.
miR-182-5p在组织组之间表现出高的区分能力 (AUC > 0.8).
特定的miRNA显示与临床结果的关联:miR-141-3p (复发),miR-661 (瘤大小) 和miR-150-5p (瘤大小,p53表达,复发,转移,生存).

结论:

对CNA和miRNA的综合分析对于理解TNBC中的分子机制至关重要.
患者的祖先是影响TNBC分子特征和临床表现的重要因素.
已识别的miRNA可以作为拉丁裔妇女TNBC预后的潜在生物标志物.

关键词:

拉丁裔拉丁人是什么意思副本编号的修改副本编号的修改这是一个小RNARNA.这是一个微型RNA.三重阴性乳腺癌是什么

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