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Updated: Jul 16, 2025

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向致癌突变p53和BCL-2用于小细胞肺癌治疗

Victoria Neely1, Alekhya Manchikalapudi1, Khanh Nguyen1

  • 1Philips Institute for Oral Health Research, School of Dentistry, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.

International journal of molecular sciences
|September 9, 2023
PubMed
概括

某些小细胞肺癌 (SCLC) 细胞由于突变的p53.3而抵抗venetoclax. 将venetoclax与像ganetespib这样的HSP90抑制剂结合使用,可以通过向BCL-2和瘤原体p53.3来克服这种抵抗.

关键词:
在BCL-2中.这就是BIM BIM.在HSP90中,它是HSP90的.他们得到了spibib.在 p53 里,p53 是一个 p53 的类型.小细胞肺癌是一种小细胞肺癌.有针对性的治疗.维尼托克莱克斯 (Venetoclax) 是一个

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