关于内皮功能障碍在小血管疾病中的生物标志物的范围审查:来自人类研究的分子见解
Daniela Jaime Garcia1,2, Audrey Chagnot2, Joanna M Wardlaw1,2
1Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
International journal of molecular sciences
|September 9, 2023
概括
小血管疾病 (SVD) 涉及大脑微血管功能障碍和受损的血脑屏障 (BBB),导致痴呆和中风. 本综述探讨了SVD中内皮功能障碍的生化标志物.
科学领域:
- 神经学 神经学
- 血管生物学 血管生物学
- 生物化学 生物化学
背景情况:
- 小血管疾病 (SVD) 是一种流行的大脑疾病,影响微血管.
- 它是痴呆症,缺血性中风和出血性中风的重要原因.
- 内皮功能障碍和受损的血脑屏障 (BBB) 都与SVD的发病有关.
研究的目的:
- 审查SVD中内皮功能障碍的分子机制.
- 在生物流体中识别内皮功能障碍的生化标志物.
- 探索潜在的诊断,预后和治疗应用.
主要方法:
- 临床研究的范围审查.
- 专注于SVD中内皮功能障碍的分子机制.
- 在生物流体中分析生化标志物.
主要成果:
- 内皮功能障碍和BBB妥协是SVD的关键.
- 各种生物化学标记物 (粘附分子,细胞因子等). 与SVD相关联.
- 这些标志物为疾病机制提供了洞察力.
结论:
- 了解SVD的分子基础至关重要.
- 生物化学标记可以帮助诊断和预后.
- 向内皮功能障碍可能提供治疗策略.
相关概念视频
The Blood-brain Barrier
Overview
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...


