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在2019年轻型冠状病毒疾病后,腺素降解活性和内皮功能障碍的变化

Agata Jedrzejewska¹, Ada Kawecka¹, Alicja Braczko¹

¹Department of Biochemistry, Medical University of Gdansk, 80-211 Gdansk, Poland.

International journal of molecular sciences

|September 9, 2023

概括

这项研究发现,在COVID-19后,腺脱氨酶 (ADA) 异酶活动发生变化,可能会影响炎症和微血管功能. 这些发现表明ADA在长期COVID心血管并发症中的作用.

科学领域:

生物化学生物化学
免疫学免疫学免疫学
心血管科学心血管科学

背景情况:

内皮细胞是SARS-CoV-2的目标.
血管腺脱氨酶1 (ADA1) 表明内皮激活,而 ADA2 影响免疫细胞.
在COVID-19后观察到微血管功能障碍和炎症.

研究的目的:

在轻度的COVID-19后8周调查循环的ADA异酶活动.
为了将ADA活动与炎症和内皮功能参数相关联.
探索CD26在COVID-19后ADA复杂化中的作用.

主要方法:

在COVID-19后的患者和对照中评估了血清总ADA,ADA1和ADA2活动.
测量了炎症标志物 (sICAM-1,TNFα,IL-10) 和内皮功能参数.
量化了循环中的CD26水平.

主要成果:

后COVID-19患者显示微血管功能障碍和改变的炎症标志物.
血清总ADA和ADA2活动减少,而ADA1保持不变.
ADA1与内皮激活标志物相关; ADA2与IL-10相关.
在COVID-19后的患者中,循环中的CD26水平较低.

结论:

在轻度的COVID-19之后,ADA异酶活动发生变化.
在ADA1和ADA2的变化可能会导致COVID-19后的炎症和微血管功能障碍.
减少的CD26表明改变了ADA1复杂化,可能影响心血管并发症.

关键词:

在 COVID-19 疫情中,腺氨酸脱氨酶的使用.它们的内皮质 (endothelium).微血管功能障碍微血管功能障碍

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