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内皮损伤,中性细胞外细胞陷和血小板激活在COVID-19与社区获得的肺炎:一个病例对照研究

Paula González-Jiménez^1,2,3, Raúl Méndez^1,2,3,4, Ana Latorre²

¹Pneumology Department, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain.

International journal of molecular sciences

|September 9, 2023

概括

内皮损伤和免疫血栓形成的生物标志物在COVID-19和社区获得性肺炎 (CAP) 之间有所不同. 虽然COVID-19患者的住院死亡率较高,但CAP患者的长期死亡率和心血管问题更高.

科学领域:

心血管医学心血管医学
传染性疾病传染性疾病
肺部病理学肺部病理学

背景情况:

COVID-19带来了独特的诊断和治疗挑战,与其他肺炎病因不同.
了解内皮损伤和免疫血栓形成的机制对于治疗肺炎至关重要.
社区获得性肺炎 (CAP) 作为COVID-19病理生理学的关键比较标准.

研究的目的:

为了比较COVID-19和CAP之间的内皮损伤和免疫血栓形成的生物标志物.
评估这些生物标志物与住院和长期结果的关联.
为了阐明COVID-19和CAP的独特病理生理学特征.

主要方法:

一项涉及358名住院肺炎患者 (179名COVID-19,179名匹配CAP) 的病例控制研究.
测量内皮损伤标记物 (内皮素,前腺腺素),NETs (素-3基因素,cfDNA) 和血小板激活 (溶性P-选择素).
评估住院和1年随访结果,包括死亡率和心血管并发症.

主要成果:

与COVID-19相比,CAP中的内皮损伤,血小板激活和NET生物标志物显著高于COVID-19.
COVID-19患者在医院死亡率较高.
CAP患者的1年死亡率和心血管并发症增加.

结论:

COVID-19和CAP显示了内皮损伤和中性粒细胞外细胞陷 (NET) 表达的不同模式.
腺美杜林 (proADM) 和内末林是肺炎中短期和长期死亡率的显著预测因素.
这些发现突出了与COVID-19和CAP相关的不同病理生理路径和长期风险.

关键词:

在CAP CAP中,我们可以使用CAP.在 COVID-19 疫情中,案例控制情况脑内皮损伤脑内皮损伤中性粒细胞外细胞陷血小板激活是什么意思

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