肠道微生物组失生症作为儿童非发病性脚行走的潜在危险因素:一篇评论
Svetlana Kononova1, Mikhail Kashparov2,3, Wenyu Xue4
1Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Russia.
International journal of molecular sciences
|September 9, 2023
概括
异常脚行走 (ITW) 可能与影响神经递质生产的肠道微生物组失衡有关. 对这种肠-脑轴连接的进一步研究可能会揭示ITW的新治疗策略.
科学领域:
- 儿科整形外科 儿科整形外科
- 神经科学是一个神经科学.
- 微生物组研究 微生物组研究
背景情况:
- 异常脚行走 (ITW) 影响大约5%的儿童,由于未知的原因,提出了复杂的骨科挑战.
- 目前对ITW的治疗方法产生了不一致的结果,突出了对新的病因学见解的需求.
- 新出现的证据表明,在一些患有ITW的儿童中,遗传因素和感觉运动障碍.
研究的目的:
- 探索肠道微生物组变化与特异性脚行走 (ITW) 之间的潜在联系.
- 提出一个理论框架,将肠道失调,神经递质失衡和感觉运动功能障碍与ITW联系起来.
- 倡导进一步调查微生物组在ITW病因学中的作用.
主要方法:
- 对涉及感觉运动功能障碍和肠道失调症的病理学现有研究的审查.
- 关于肠道微生物群代谢物影响神经递质生产的假设的理论证据.
- 分析微生物组变异与脚行走 (TW) 之间的潜在联系.
主要成果:
- 在ITW中的感觉运动功能障碍可能源于神经递质产生的不平衡.
- 肠道功能障碍及其代谢物可能是导致神经递质功能障碍的因素.
- 建议肠道微生物组的改变和ITW的发展之间存在理论上的联系.
结论:
- 肠道微生物组代表了一个有希望的,但未被充分探索的领域,用于理解ITW病因学.
- 在ITW中调查肠-大脑轴可能会揭示新的诊断和治疗目标.
- 需要进一步的研究来验证微生物组变异和ITW之间提出的联系.
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