结质瘤瘤微环境的标志及其与新兴免疫疗法模式的相互作用
Christian A Linares1, Anjana Varghese2, Aruni Ghose3,4,5,6
1Guy's Cancer Centre, Guy's and St Thomas' NHS Foundation Trust, London SE1 9RT, UK.
International journal of molecular sciences
|September 9, 2023
概括
质瘤,特别是质母细胞瘤,由于其免疫抑制性瘤微环境 (TME),预后不好. 免疫疗法是有前途的,但克服TME耐药性对于改善质瘤治疗结果至关重要.
科学领域:
- 神经瘤学神经瘤学
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 质瘤,包括恶性质母细胞瘤,是主要的中枢神经系统瘤,预后不佳.
- 目前的护理标准受到异质和免疫抑制瘤微环境 (TME) 的限制,该微环境促进免疫逃避和瘤增殖.
研究的目的:
- 审查质瘤TME的免疫生物学标志.
- 了解TME如何逃避免疫疗法.
- 讨论克服TME介导的免疫疗法抵抗性在质瘤中的策略.
主要方法:
- 目前关于质瘤免疫学和免疫疗法的文献综述.
- 分析质瘤TME抑制抗瘤免疫力的机制.
- 检查新兴的免疫疗法模式和组合策略.
主要成果:
- 质瘤TME的特点是免疫抑制因素阻碍有效的抗瘤免疫反应.
- 各种免疫疗法方法,包括免疫检查点抑制剂,癌症疫苗,瘤病毒和细胞疗法 (CAR T / NK 细胞),显示出潜力.
- 组合免疫疗法在临床试验中成功克服了TME耐药性,从而改善了生存效益.
结论:
- 解决免疫抑制性TME对于推进质瘤免疫疗法至关重要.
- 需要开发具有成本效益和高通量免疫疗法策略,以便在现实世界中应用.
- 新型免疫疗法的成功实施可能会大大改变质瘤治疗的前景.
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