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蛋白二硫酸异构酶A3 (PDIA3):在质母细胞瘤中是一种药理性标?

Giuliano Paglia1, Marco Minacori1, Giorgia Meschiari1

  • 1Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.

International journal of molecular sciences
|September 9, 2023
PubMed
概括

在质母细胞瘤细胞中抑制蛋白二硫化异构酶A3 (PDIA3) 会引发细胞死亡和DNA损伤. 这种抑制也增加了对temozolomide的敏感性,这表明PDIA3是治疗点.

关键词:
在ERP57中,有57个项目.在PDIA3中,癌症 癌症 癌症 癌症 癌症质母细胞瘤是什么抑制剂抑制剂的作用蛋白质二硫化异硫酶酶是什么这种疾病是Punicalagin.泰莫索洛米德 (temozolomide) 是一种有毒的物质.

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Protein Modifications in the RER

Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal sequences.