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代谢学:关于自闭症谱系障碍临床就业的观点

Martina Siracusano^1,2, Lucrezia Arturi², Assia Riccioni²

¹Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

International journal of molecular sciences

|September 9, 2023

概括

代谢学在早期自闭症谱系障碍 (ASD) 诊断和理解其多样化的临床特征方面表现有前途. 需要进一步的研究来将这些强大的诊断工具整合到常规临床实践中.

科学领域:

生物化学生物化学
遗传学遗传学是一个
神经科学是一个神经科学.

背景情况:

精准医学正在进步,代谢学正在成为一个关键参与者.
自闭症谱系障碍 (ASD) 诊断和管理可以从新的方法中受益.
代谢学提供了对遗传学和环境因素之间的相互作用的见解.

研究的目的:

对自闭症谱系障碍 (ASD) 中代谢技术的临床应用进行文献审查.
探索代谢学在早期ASD诊断,表型和识别并发症方面的潜力.
评估当前代谢分析对临床诊断程序的准备程度.

主要方法:

使用PubMed,Medline和谷歌学者进行了全面的文献审查.
包括在2010年至2022年间发表的37项研究.
分析了2079名自闭症患者,51名并发症患者,182名风险患者和1530名健康对照者的数据.

主要成果:

代谢学反映了ASD中遗传学和环境的复杂相互作用.
"代谢型"可能反映出ASD的临床异质性,代谢物表明失调的途径.
代谢概况显示出定义临床表型和识别并发疾病的潜力.

结论:

代谢学是一种创新和有前途的技术,用于接近ASD.
代谢组药物具有显著的潜力,可以改善ASD的早期诊断和临床表型.
将代谢分析从研究转变为常规的临床实践需要进一步的研究.

关键词:

自闭症谱系障碍自闭症谱系障碍生物标志物生物标志物临床特征临床特征临床特征早期检测早期检测食品的选择性食品的选择性胃肠道问题胃肠道问题代谢代谢代谢代谢代谢生物组的代谢生物组现象型现象型是一种现象型.睡眠障碍睡眠障碍睡眠障碍

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