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构成和尺寸对抗癌纳米粒子表面性能的影响

Ina Mishra1, Meredith Garrett1, Stephen Curry1

  • 1Department of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

International journal of molecular sciences
|September 9, 2023
PubMed
概括

界面张力测量可以帮助表征脂质体药物递送系统,有助于开发和制造. 这种方法可以检测PEG含量,药物存在和颗粒大小的变化,以提高质量控制.

关键词:
德克西尔 (Doxil®) 的使用方法临床翻译 临床翻译表面之间的张力.脂质体是一种脂质体.纳米颗粒是一种纳米粒子.

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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