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Updated: Jun 20, 2026

A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation
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对SARS-CoV-2蛋白酶抑制剂进行查,合成和生物化学表征

Martynas Bagdonas1, Kamilė Čerepenkaitė1, Aurelija Mickevičiūtė1

  • 1Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio 7, LT-10257 Vilnius, Lithuania.

International journal of molecular sciences
|September 9, 2023
PubMed
概括

研究人员选了1300种化合物,以找到SARS-CoV-2蛋白酶的抑制剂. 他们确定了与帕帕因类蛋白酶 (PLpro) 结合的二硫化物化合物,显示了COVID-19药物开发的潜力.

关键词:
这就是SARS-CoV-2病毒.不同扫描光仪的差异扫描光仪.硫化二氧化物是什么?抑制抑制抑制的抑制作用主要蛋白质酶的主要蛋白质酶帕帕因类蛋白酶是一种类似帕帕因的蛋白酶.热转移测试试验 热转移测试提亚醇的使用方法

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