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相关概念视频

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
285
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

213
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
213
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

478
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
478
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
354
Gastritis-I: Introduction and Types01:27

Gastritis-I: Introduction and Types

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Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
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Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
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炎症和消化系统癌症 消化系统癌症

Helge Waldum1, Reidar Fossmark1

  • 1Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7030 Trondheim, Norway.

International journal of molecular sciences
|September 9, 2023
PubMed
概括

胃和肝脏等消化器官的慢性炎症可能导致癌症. 本综述探讨了慢性胃炎,特别是来自Helicobacter pylori的胃炎,如何导致消化器官癌症发生.

科学领域:

  • 胃肠道学和瘤学
  • 癌症发生的机制.

背景情况:

  • 慢性炎症是已知的消化器官癌症发展的危险因素,包括胃,结肠和肝脏.
  • 诸如慢性肝炎,炎症性肠病和慢性胃炎等疾病使个人易患恶性瘤.

研究的目的:

  • 审查慢性炎症有助于消化器官致癌的机制.
  • 专注于慢性胃炎,探索其在癌症发展中的作用,特别是与Helicobacter pylori感染有关.

主要方法:

  • 文献综述,重点关注慢性炎症疾病及其与消化器官癌症的联系.
  • 分析了将慢性炎症与恶性瘤联系在一起的四种拟议机制:原因的基因毒性,炎症媒介的基因毒性,补偿性增殖和荷尔蒙乱.

主要成果:

  • 乙型肝炎病毒的基因毒性是肝细胞癌的关键因素.
  • 病毒感染是炎症性肠道疾病和相关恶性瘤的病因的核心.
  • 慢性胃炎的主要原因是Helicobacter pylori,它没有直接的基因毒性,但可以通过缩性氧化性胃炎和超胃炎引起癌症.

结论:

  • 慢性炎症通过多种机制在消化器官的癌症发生中发挥着重要作用.
  • 由Helicobacter pylori引起的慢性胃炎是导致胃癌的关键途径,主要是通过高胃血症.
关键词:
癌症发生的原因是癌症发生.慢性胃炎 慢性胃炎慢性肝炎是一种慢性肝炎.结肠癌是什么意思结肠癌是什么意思胃癌 胃癌 是一种胃癌.肝细胞癌是肝细胞癌.荷尔蒙致癌的产生这是一种炎症炎症炎症炎症.炎症性肠病是一种炎症性肠病.这是一个机制机制.

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  • 了解这些炎症途径对于制定预防消化器官癌症的策略至关重要.