纤维和结肠直肠癌:临床和分子证据
Francesca Celiberto1,2, Adriana Aloisio1, Bruna Girardi3
1Section of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, Italy.
International journal of molecular sciences
|September 9, 2023
概括
高纤维摄入量可能会降低结肠直肠癌 (CRC) 风险并改善预后. 食纤维影响肠道微生物群并产生有益的化合物,为CRC提供了一个有希望的预防策略.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因.
- 饮食习惯显著影响CRC的发展和预后.
- 在西方国家,纤维摄入不足很普遍,与CRC发病率增加有关.
研究的目的:
- 探索饮食纤维摄入量与结直肠癌风险和预后之间的关联.
- 调查纤维影响CRC的潜在机制.
- 评估高纤维饮食在CRC预防中的作用.
主要方法:
- 检查每日纤维摄入量与CRC风险之间的关系的流行病学研究.
- 对涉及纤维,胆汁酸,抗氧化剂和肠道微生物群的潜在病原机制的分析.
- 审查正在进行的饮食干预措施,使用高纤维饮食预防CRC.
主要成果:
- 流行病学研究表明,日常纤维摄入量与CRC风险之间存在逆关系.
- 食纤维可能通过调节胆酸代谢,富含纤维的食物中的抗氧化剂含量,抗增殖化合物如丁酸盐的产生和肠道微生物群的改变影响CRC.
- 对于预防CRC的高纤维饮食干预措施的初步结果令人鼓舞.
结论:
- 食纤维在结直肠癌的发展和长期预后中起着至关重要的作用.
- 机制包括影响肠道微生物群,产生有益的代谢物,并与胆酸代谢相互作用.
- 富含纤维的饮食干预措施对CRC预防有前途,特别是在高风险人群中.
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