阿尔茨海默病:肥胖和APOE基因多态性之间的因果关系
Tianyu Zhao1, Tangsheng Zhong2, Meishuang Zhang2
1Department of Pharmacology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130012, China.
International journal of molecular sciences
|September 9, 2023
概括
肥胖与阿尔茨海默病 (AD) 主要通过Apolipoprotein E (APOE) 基因联系在一起,而不是脂肪分布. 在APOE3载体中管理身体脂肪可能会降低AD风险.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 肥胖和阿尔茨海默病 (AD) 之间的关系尚不清楚.
- 现有的研究经常使用有限的肥胖指标,阻碍对身体脂肪对AD的影响进行全面分析.
- 需要确定关键的分子标和肥胖指标与AD病原体之间的因果关系.
研究的目的:
- 使用生物信息学识别关键的分子标,将肥胖与阿尔茨海默病 (AD) 联系起来.
- 通过孟德尔随机化 (MR) 调查各种肥胖指标与这些目标之间的因果关系.
- 澄清身体脂肪质量和分布在与肥胖相关的AD中的作用.
主要方法:
- 使用GeneCards数据库选肥胖和AD的常见目标.
- 执行功能和路径注释以确定关键目标.
- 使用IVW模型进行孟德尔随机化 (MR) 分析,使用人体人体指数和确定目标的IVW模型.
主要成果:
- 鉴定出Apolipoprotein E (APOE) 是连接肥胖和AD的关键目标.
- 身体质量指数 (BMI),身体脂肪百分比 (BFP) 和干脂肪百分比 (TFP) 显示与APOE3.3存在负因果关系.
- 在BMI,BFP,TFP和APOE2或APOE4.4之间没有发现显著的因果关系.
结论:
- 肥胖与AD的相关性主要由APOE基因多态性介导,而不是脂肪组织分布.
- 携带APOE3的携带者可能会增加对肥胖的易感性,可能会增加AD风险.
- 肥胖可能不是APOE2和APOE4载体中AD的直接因果因素;建议APOE3载体中早期体脂调节以减轻AD风险.
更多相关视频
相关概念视频
01:28Human Genetics
610
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
610
01:26Alzheimer's Disease: Overview
517
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
517
01:24Obesity
534
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
534
01:11Genome-wide Association Studies-GWAS
13.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.6K
02:41Lethal Alleles
15.5K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
15.5K
01:30Coronary Artery Disease I: Introduction
20
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
20