神经结构-功能:不寻常的结构细节和硫基组的电刺激或窒息在轴膜和隙连接处的电刺激或窒息的揭露
1Department of Pharmacology and Physiology, School of Medicine and Dentistry, University Rochester, Rochester, NY 14642-8711, USA.
International journal of molecular sciences
|September 9, 2023
概括
观察到鱼轴突中不寻常的结构细节,包括状和膜融合. 电刺激或窒息揭示了轴体膜中的硫基,表明膜的特性发生了变化.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 生物物理学的生物物理.
背景情况:
- 轴突运输依赖于复杂的结构和分子机制.
- 膜性质对于神经元功能和对刺激的反应至关重要.
- 硫基团在蛋白质结构和膜完整性中起着重要的作用.
研究的目的:
- 描述鱼轴突中的不寻常的结构特征.
- 为了研究在生理压力下轴质细胞膜的变化.
- 探索硫基在对刺激和窒息的轴突反应中的作用.
主要方法:
- 电子显微镜和相对比显微镜被用来检查轴突结构.
- 采用冷断裂技术来分析膜传单的细节.
- 在正常,刺激和窒息条件下对固定轴突进行比较分析.
主要成果:
- 确定了带有微管所占用的毛孔和桥梁纤维的窗口性七面体.
- 观察到轴突-质膜投射和形成细胞间毛孔的融合.
- 电刺激和窒息导致电子不透明度增加,各种膜的厚度增加,这是由于硫基团的揭露.
结论:
- 鱼轴突具有独特的结构元素,如状,可能参与轴质流动.
- 轴突-质相互作用包括复杂的膜曲率和融合.
- 揭露硫基组表明神经元应激期间膜组成和状态的显著变化.
关键词:
戈尔吉仪器是一台高尔吉仪器.窒息症 (asphyxia) 是一种窒息症.轴子 轴子 轴子类的类的鱼类.电刺激是一种电刺激.细胞内膜网膜的内oplasmic网膜.差距连接点 差距连接点 差距连接点线粒体中的线粒体.神经是神经,神经是神经血膜是一种等离子体膜.硫基团是硫基团的组成部分.更多相关视频
07:40Measuring Properties of the Membrane Periodic Skeleton of the Axon Initial Segment using 3D-Structured Illumination Microscopy 3D-SIM
Published on: February 11, 2022
2.1K
14:28Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis
Published on: March 16, 2016
6.2K
相关概念视频
Neuron Structure
13.1K
Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
13.1K
Action Potentials
131.3K
Overview
131.3K
Action Potential
8.0K
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...
8.0K
Electrical Synapses
8.4K
Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
8.4K
Nervous Tissue: Myelin
2.7K
The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
2.7K
Overview of Synapses
2.4K
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the synapse and bind to...
2.4K
