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针对癌症的向治疗:从正在进行的临床试验到FDA批准的药物

Ha Yeong Choi¹, Ji-Eun Chang¹

¹College of Pharmacy, Dongduk Women's University, Seoul 02748, Republic of Korea.

International journal of molecular sciences

|September 9, 2023

概括

向疗法提供有效的癌症治疗,副作用较少. 本综述涵盖了FDA批准的针对肺癌,结直肠癌和前列腺癌的向药物,重点关注EGFR,ALK和AR等关键分子标.

科学领域:

在瘤学瘤学.
药理学药理学是指药理学的学科.
分子生物学分子生物学

背景情况:

针对性疗法比传统化疗有显著的进步,提供更好的疗效和减少副作用.
该综述侧重于针对性治疗在三个主要癌症类型的当前景观:肺癌,结肠直肠癌和前列腺癌.

研究的目的:

审查目前针对肺癌,结肠直肠癌和前列腺癌的向治疗的现状.
要突出关键的分子标及其相应的美国食品和药物管理局 (FDA) 批准的药物.
讨论新兴的目标和正在进行的临床试验,塑造癌症治疗的未来.

主要方法:

针对性疗法及其在特定癌症中的分子标的文献综述.
专注于FDA批准的药物和候选药物.
确定这些疗法所针对的关键分子途径和遗传改变.

主要成果:

肺癌:EGFR突变和ALK重组是FDA批准的药物如 osimertinib 和 crizotinib 的目标.
结肠直肠癌:VEGF和EGFR是主要点,FDA批准的药物包括贝瓦西祖马布和塞图西马布.
前列腺癌:雄激素受体 (AR) 信号的向是恩扎胺,阿帕胺和达罗胺在抵抗割的病例中.

结论:

向疗法通过精确向分子变化,彻底改变了癌症治疗.
经FDA批准的药物在肺癌,结直肠癌和前列腺癌中表现出显著的疗效.
新兴的目标和正在进行的研究有望在个性化癌症治疗方面取得进一步的进步.

关键词:

美国食品和药物管理局批准的药物.针对癌症的向治疗临床试验是指临床试验中的临床试验.结肠直肠癌是什么意思肺癌是一种肺癌.前列腺癌是前列腺癌.

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