在稳定冠状动脉疾病中,可溶性触发受体表达在髓状细胞类转录-1上的表征和评估
Zaida Bayrón-Marrero1, Siobhan Branfield1,2, Javier Menéndez-Pérez1
1Department of Biology, University of Puerto Rico-Rio Piedras, San Juan, PR 00936, USA.
International journal of molecular sciences
|September 9, 2023
概括
溶性触发受体表达在骨髓细胞样转录-1 (sTLT-1) 水平在冠状动脉疾病患者与左心室功能障碍较低. 较低的sTLT-1与充血性心力衰竭有关,表明其作为生物标志物的潜力.
科学领域:
- 生物化学 生物化学
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 血小板是冠状动脉疾病 (CAD) 进展的关键.
- 从激活的血小板中释放的状细胞样转录-1 (sTLT-1) 中表达的可溶性触发受体是一种潜在的生物标志物.
- 了解sTLT-1的特征和在CAD中的作用至关重要.
研究的目的:
- 为了描述sTLT-1的氨基酸组成.
- 评估sTLT-1作为稳定冠状动脉疾病 (CAD) 患者的生物标志物.
- 调查sTLT-1水平与CAD的临床结果之间的关联.
主要方法:
- 免疫沉和质谱法被用于识别sTLT-1残留物和裂变部位.
- 在1510名稳定的CAD患者中,ELISA测量了血sTLT-1度.
- 统计分析将sTLT-1水平与临床结果相关联,包括左心室 (LV) 功能和主要心脏事件.
主要成果:
- 确定了高达133个TLT-1残留物;ADAM17裂变表明S136是sTLT-1的C端氨基酸.
- 在主要结局 (死亡,主要心脏事件) 中没有观察到sTLT-1水平的显著差异.
- 与正常LV功能患者相比,患有LV功能障碍的CAD患者的sTLT-1水平显著降低 (p=0.003).
- 较低的sTLT-1水平 (低于544 pg/mL) 与充血性心力衰竭 (OR=2.94,p=0.042) 有显著的关联,可能是由于LV功能障碍.
结论:
- sTLT-1的表征提供了对其结构和释放机制的见解.
- 血sTLT-1水平不能预测稳定的CAD中主要的不良心脏事件.
- 降低的sTLT-1水平与CAD患者的LV功能障碍和充血性心力衰竭有关,这表明它可能是这些疾病的生物标志物.
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