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在人类肥胖引起的慢性脏疾病中脏内大麻素失调
Anna Permyakova1, Ariel Rothner1, Sarah Knapp2
1Obesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel.
International journal of molecular sciences
|September 9, 2023
概括
肥胖会改变人类脏中的内分泌大麻素系统 (ECS),增加损伤和纤维化标志物. 这项研究揭示了与男性肥胖诱导的慢性脏病 (CKD) 相关的特定内分泌素变化.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢过程中的代谢.
背景情况:
- 内分泌大麻素系统 (ECS) 调节能量平衡和功能.
- 肥胖与慢性病 (CKD) 有关,在动物模型中观察到ECS变化.
- 肥胖对人类脏ECS的影响在很大程度上仍未被探索.
研究的目的:
- 为了研究肥胖对人类脏内内可纳素系统 (eCB) 的影响.
- 确定肥胖与瘦身男性中脏eCBs,损伤和纤维化之间的关系.
- 阐明ECS在与肥胖相关的功能障碍中的作用.
主要方法:
- 从21名瘦身和肥胖男性的脏活检分析了形态学,生物化学和eCB水平.
- 评估包括损伤和纤维化标志物,以及大麻素-1受体 (CB1R) 表达.
- 进行了相关性分析,以将脏eCB与临床参数联系起来.
主要成果:
- 肥胖男性显示出显著的损伤,纤维化标志物的增加,以及改变的eCB配置文件,特别是脏组织中的胺含量较高.
- 在肥胖脏中观察到CB1R表达的减少和eCB代谢酶的活性变化.
- 血清eCB水平没有差异,但脏eCB与肥胖,脏损伤和纤维化标志物相关.
结论:
- 肥胖严重影响人类的脏内分泌系统,导致脏损伤和纤维化.
- 脏eCBs和CB1R表达的特定变化与肥胖引起的脏疾病有关.
- 这些发现强调了ECS作为管理与肥胖相关的CKD的潜在治疗目标.
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