线素激活蛋白激酶和核激素受体在癌症免疫治疗中的交叉
1Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany.
International journal of molecular sciences
|September 9, 2023
概括
线素激活蛋白激酶 (MAPK) 途径调节核激素受体 (NHRSF),影响癌症和免疫力. 针对这些途径为新型癌症免疫疗法提供了潜力.
科学领域:
- 分子生物学分子生物学
- 癌症研究 癌症研究
- 免疫学 免疫学 免疫学
背景情况:
- 中原激活蛋白激酶 (MAPK) 途径 (ERK1/2,p38,JNK/SAPK) 是核激素受体超级家族 (NHRSF) 的关键调节者.
- 像雌激素受体一样,NHRSF在癌症,特别是乳腺癌中发挥着关键作用.
- MAPK路径和NHRSF之间的交叉交谈影响了参与细胞功能和免疫反应的基因转录.
研究的目的:
- 对人类瘤 (固体和白血病) 的NHRSF子类的文献进行审查.
- 探索NHRSFs在瘤微环境中的功能作用,包括免疫细胞.
- 讨论针对MAPK和NHRSF通路的治疗潜力,特别是在癌症免疫治疗中.
主要方法:
- 对现有关于NHRSF表达和功能在各种人类癌症中的研究的文献综述.
- 在癌细胞和免疫细胞中分析MAPK信号与NHRSF之间的相互作用.
- 检查涉及NHRSF和免疫检查点抑制剂 (例如PD1) 的联合治疗策略.
主要成果:
- NHRSFs在各种人类瘤中表达,包括固体癌症和白血病.
- MAPK和NHRSF通路之间的相互作用影响瘤微环境中的关键细胞过程和免疫调节.
- NHRSF在免疫细胞中发挥了功能性作用,影响了适应性和先天性免疫系统对瘤的反应.
结论:
- 无论是MAPK还是NHRSF途径的可用性,都为开发新型癌症疗法提供了重大机会.
- 针对NHRSF的组合疗法与现有的免疫疗法,如PD1抑制剂,显示出增强癌症免疫疗法的希望.
- 对MAPK,NHRSF和免疫系统之间的分子交叉声的进一步研究对于推进精确瘤学至关重要.
相关概念视频
Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
MAPK Signaling Cascades
5.6K
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
5.6K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Signal Transduction: Overview
8.6K
Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Typically, signal transduction involves three...
8.6K
Tumor Immunotherapy
554
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
554


