通过性别和性别镜头研究癌症表观遗传学:全面的范围审查
Katherine Huerne1, Sarah S Jackson2, Rina Lall3
1Center of Genomics and Policy, Department of Human Genetics, McGill University, Montreal, QC H3A 0G1, Canada.
Cancers
|September 9, 2023
概括
癌症表观遗传学研究很少定义或始终使用性别和性别. 大多数研究将这些术语结合在一起,强调需要明确的指导方针来改善这一领域的性别和基于性别的分析 (SGBA).
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 公共卫生 公共卫生
背景情况:
- 性别和性别显著影响癌症的发展和进展.
- 表观遗传机制在癌症中至关重要,但性别和性别方面的考虑往往被忽视.
- 需要对癌症表观遗传学研究中的性别和基于性别的分析 (SGBA) 进行全面评估.
研究的目的:
- 批判性地评估自2010年以来发表的癌症表观遗传学研究中性别和性别的代表性,讨论和数据分析.
- 评估在报告性别和性别变量方面遵守最佳实践.
- 确定SGBA在现场应用中的差距和不一致性.
主要方法:
- 使用了PRISMA-ScR范围审查方法.
- 包括111项专注于结直肠,胃,头,肝细胞癌和肺癌的同行评审研究.
- 数据提取和质量评估由流行病学家和生物伦理学家进行.
主要成果:
- 只有15.3%的研究明确旨在分析性别和性别.
- 虽然92.8%的人分析了性别/性别,但只有6.3%的人定义了这些术语,75.7%的人混了它们.
- 观察到术语和性别/性别变量的应用存在重大不一致.
结论:
- 大多数癌症表观遗传学研究缺乏根据既定指南 (例如,SAGER) 进行强有力的性别和性别分析.
- 对于在表观遗传学研究中将性别和性别作为变量使用的明确,有针对性的指导方针至关重要.
- 改进SGBA对于推进我们对癌症病因学的理解和开发公平的治疗方法至关重要.
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