一个第二阶段,单臂,开放标签临床试验,用于在经过手术和化疗的具有侵略性血管肉瘤的狗中进行辅助性基疫苗接种
Laura Marconato1, Luca Tiraboschi2, Marina Aralla3
1Department of Veterinary Medical Sciences, Alma Mater Studiorum University of Bologna, Ozzano dell'Emilia, 40064 Bologna, Italy.
Cancers
|September 9, 2023
概括
一种基于的新型癌症疫苗,来源于犬血类肉瘤细胞,显著改善了接受标准治疗的狗的生存时间. 这种疫苗表现出抗瘤作用和良好的安全性,为未来的临床研究带来了希望.
科学领域:
- 兽医瘤学 兽医瘤学
- 免疫治疗是一种免疫疗法.
- 癌症生物学 癌症生物学
背景情况:
- 狗血肉瘤是一种具有有限治疗选择的侵袭性癌症.
- 标准护理 (SOC) 包括手术和多克索鲁比辛化疗.
- 需要新的治疗策略来改善患有血管肉瘤的狗的治疗结果.
研究的目的:
- 为了评估一种基于的疫苗在患有血肉瘤的狗中抗瘤疗效和安全性.
- 评估疫苗对进展时间 (TTP) 和整体存活率 (OS) 的影响.
- 为了研究疫苗产生的免疫反应.
主要方法:
- 狗血肉瘤细胞被感染了Salmonella typhi Ty21a以从释放的中制造疫苗.
- 狗接受了SOC加上每3周接种5剂疫苗.
- 一组对照组仅接受了SOC;结果使用连续成像和生存数据进行了比较.
主要成果:
- 基于的疫苗耐受性良好,没有观察到毒性.
- 接种疫苗的狗表现出瘤特异性幽默和疫苗特异性T细胞反应.
- 与对照组相比,在接种疫苗的狗中观察到TTP (195 vs. 160天) 和OS (276 vs. 175天) 的显著改善.
结论:
- 基于的疫苗,当与SOC结合时,在患有血肉瘤的狗中显著增加了TTP和OS.
- 该疫苗显示出安全的特征,并诱导瘤特异性免疫反应.
- 这些发现支持对这种基于的免疫疗法的进一步临床试验的可行性.
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