与黄金标准螺旋式托莫疗法相比,使用线性加速器为基础的放射性外科治疗系统使用VMAT优化符合整体照射
Mümtaz Köksal1, Oğuzhan Özkan1, Tobias Holderried2
1Department of Radiation Oncology, University Hospital of Bonn, 53127 Bonn, Germany.
Cancers
|September 9, 2023
概括
卷度调节弧线疗法 (VMAT) 和螺旋式断层疗法 (HT) 提供符合整体照射 (TBI). VMAT是HT的可行备用,提供足够的覆盖和器官节省,尽管治疗时间更长.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
背景情况:
- 现代合规全身照射 (TBI) 使用螺旋式断层疗法 (HT) 或体积调节弧线疗法 (VMAT).
- 需要研究VMAT作为HT备份的适用性,特别是对于小型现场大小,需要研究.
研究的目的:
- 为了比较VMAT和HT的剂量有效性,以优化符合性TBI.
- 评估VMAT在设备故障时作为HT的备用模式的潜力.
主要方法:
- 用10名患者的CT数据进行回顾性剂量计量规划研究.
- 在HT和VMAT之间对目标体积覆盖率,剂量均性和风险器官 (OAR) 节省 (肺,脏,透镜) 的比较.
- 对治疗时间的分析和一个用两种治疗方式治疗的患者的现实世界比较.
主要成果:
- 无论是HT还是VMAT,都实现了充分的目标剂量覆盖率和OAR剂量减少.
- 在目标体积内,HT表现出优越的剂量均性.
- VMAT导致12 Gy组的透镜的平均剂量更高,治疗时间明显更长.
结论:
- VMAT是符合TBI的HT的合适备用,提供可比的目标覆盖和OAR节省.
- 优化VMAT治疗时间对于例行临床实施是必要的.
- 使用线性加速器放射外科技术的VMAT可以集成到临床工作流程中,作为HT的替代方案或备份.
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