放射治疗和全身疗法:专注于头部和部癌症
Francesca De Felice1, Carlo Guglielmo Cattaneo1, Pierfrancesco Franco2
1Radiation Oncology, Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
Cancers
|September 9, 2023
概括
头部和部状细胞癌 (HNSCC) 的治疗需要多学科的方法. 虽然辐射疗法和化疗是标准的,但与辐射相结合的新型全身疗法正在研究以改善结果.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医学瘤学 医学瘤学
背景情况:
- 头部和部状细胞癌 (HNSCC) 提出了复杂的治疗挑战.
- 当前对局部晚期HNSCC的标准治疗包括放射治疗 (RT) 与或没有基于的化疗.
- 强度调节光子疗法 (IMPT) 是首选的RT技术,用于精确瘤向和节省关键组织.
研究的目的:
- 审查有关HNSCC治疗策略的当前文献.
- 为了提供对HNSCC的护理标准的概述.
- 专注于系统疗法与RT的整合,并强调新出现的证据和正在进行的试验.
主要方法:
- 关于HNSCC治疗的综合文献综述.
- 对标准护理方案的分析.
- 在最终设置中评估系统疗法与RT组合的评估.
主要成果:
- 有或没有化疗的放射治疗仍然是局部发达HNSCC的标准.
- 强度调节光子疗法 (IMPT) 提供了更好的治疗一致性.
- 目前的证据不支持将RT与免疫检查点抑制剂结合起来作为主要治疗,以获得显著的生存益处.
结论:
- 多学科团队讨论对于最佳的HNSCC管理至关重要.
- 迫切需要对新型全身药物与RT组合进行进一步的研究,以提高治疗比率.
- 总结当前的文献为未来的HNSCC试验设计和改善患者护理和生活质量的基础.
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