先进的非清晰细胞细胞癌治疗和生存:一个现实世界的单中心体验
Davide Bimbatti1, Francesco Pierantoni2,3, Eleonora Lai1,3
1Oncology 1 Unit, Istituto Oncologico Veneto, IOV-IRCCS, 35128 Padova, Italy.
Cancers
|September 9, 2023
概括
用免疫疗法组合治疗的高级非清晰细胞细胞癌 (nccRCC) 患者表现出改善的结果. 与单一治疗相比,组合疗法导致更好的整体反应率,无进展生存率和整体生存率.
科学领域:
- 在瘤学瘤学.
- 医学研究 医学研究
- 细胞癌研究 细胞癌研究
背景情况:
- 非清细胞细胞癌 (nccRCC) 是一种多样化的癌症.
- 目前对nccRCC的治疗指南通常基于清晰的细胞RCC数据,缺乏具体证据.
- 这项研究回顾了在一个研究所治疗的高级nccRCC患者的结果.
研究的目的:
- 评估晚期非清细胞细胞癌 (nccRCC) 患者的治疗结果.
- 为了比较不同系统性治疗的疗效及其对生存的影响.
- 分析nccRCC中的预后因素.
主要方法:
- 对121名从2008年1月起接受治疗的晚期nccRCC患者的回顾性分析.
- 基于组织学和治疗类型的整体应答率 (ORR),无进展生存率 (PFS) 和整体生存率 (OS) 的比较.
- 使用卡普兰-梅尔,日志等级测试和考克斯回归的统计分析.
主要成果:
- 患有染色恐惧症和其他nccRCC组织学的患者的存活率比 papillary RCC和未分类的RCC差.
- 与单一治疗相比,组合疗法显著改善了ORR (42.4%对13.9%),PFS (12.7对6.4个月) 和OS (30.7对13.7个月).
- IMDC和Meet-URO得分保持了他们的预后意义.
结论:
- 基于免疫疗法的组合疗法可能会增强先进的nccRCC的ORR,PFS和OS.
- 现实世界的数据表明,组合疗法优于nccRCC.TCI单疗法.
- 需要进一步的前性试验来证实这些发现,并探索新的治疗方法.
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