在多发性骨髓瘤患者中发展的第二次主要恶性瘤的结果
Irit Avivi1, David H Vesole2, Julio Davila-Valls3
1Department of Hematology, Tel Aviv Sourasky Medical Center and Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Cancers
|September 9, 2023
概括
患有多发性骨髓瘤 (MM) 的患者面临患第二次原发性恶性瘤 (SPMs) 的风险更高. 早期检测和监测至关重要,因为SPM诊断后的结果很差.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 癌症研究 癌症研究
背景情况:
- 多发性骨髓瘤 (MM) 患者患第二原发性恶性瘤 (SPMs) 的风险较高.
- 关于SPM的MM患者的特征和结果的现实数据有限.
研究的目的:
- 分析多发性骨髓瘤患者的特征和结果,这些患者患有SPMs.
- 在MM患者中确定影响SPM诊断后生存的因素.
主要方法:
- 跨国,追溯的"现实世界"研究设计.
- 对165名多发性骨髓瘤患者的分析,他们被诊断出患有第二次主要恶性瘤.
- 评估患者的人口统计,先前的治疗,SPM类型和整体存活率 (OS).
主要成果:
- 113名患者患有固体SPM,52人患有血液性SPM (例如MDS/AML).
- 血液性SPM患者更年轻,更有可能有先前的AutoHCT.
- 中位数的OS后SPM诊断是8.5个月;SPM是死亡的主要原因. 糟糕的ECOG状态预测了更短的OS,而正常的血红蛋白预测了更长的OS.
结论:
- 改善MM的整体存活率可能会导致SPM的发病率更高.
- 在MM患者中SPM诊断后的生存率很差,这强调了需要警监测和及时检测的需要.
- 早期检测策略对于改善发展SPM的MM患者的治疗结果至关重要.
关键词:
SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM SPM多发性骨髓瘤是多发性骨髓瘤的一种疾病.第二个初级恶性瘤.治疗疗法治疗疗法治疗疗法更多相关视频
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