饮食对肠道微生物群的影响:潜在的益处,风险和适应症
Andrea Santangelo1, Antonio Corsello2, Giulia Carla Immacolata Spolidoro2
1Department of Pediatrics, Santa Chiara Hospital, Azienda Ospedaliero Universitaria Pisana, 56126 Pisa, Italy.
Nutrients
|September 9, 2023
概括
性饮食 (KD) 改变肠道微生物群和表观遗传学,显示出治疗潜力,但需要对长期影响和风险进行更多研究,特别是在年轻人中. 这种饮食会影响新陈代谢和神经条件.
科学领域:
- 营养科学 营养科学
- 微生物学 微生物学
- 生物化学 生物化学
背景情况:
- 性饮食 (KD) 是一种高脂肪,低碳水化合物饮食,可诱导症,利用体作为能量.
- 肯德基已经显示出对各种疾病的治疗益处,特别是在儿童的神经疾病中.
- 新出现的证据表明,KD影响肠道微生物群,影响宿主新陈代谢,免疫力和神经系统发育.
研究的目的:
- 审查30年来关于饮食影响的研究,重点关注其对肠道微生物群和表观遗传机制的影响.
- 探索KD的潜在治疗应用和相关风险.
- 强调需要进一步研究长期KD的疗效和安全性,特别是在青少年和年轻人.
主要方法:
- 这项研究是对过去30年出版的文献进行叙事审查.
- 该审查综合了KD生物化学影响,治疗用途和对肠道微生物组成的影响的发现.
- 它检查了KD对表观遗传修饰和细胞内途径的影响.
主要成果:
- 性饮食显著影响肠道微生物的组成和表观遗传机制.
- 短期KD研究提供了对肠道微生物群变化的洞察力,但长期影响和失生症的可能性仍然不确定.
- 凯迪显示出对体重管理,血糖控制和神经疾病的潜力.
结论:
- 性饮食由于其对表观遗传学和肠道微生物群的影响,具有治疗性前景.
- 长期坚持KD需要仔细考虑潜在风险和营养状况.
- 进一步的研究对于充分了解KD对肠道微生物群和整体健康的影响至关重要,特别是在年轻人群中.
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