基因预测的蔬菜摄入量和心血管疾病和风险因素:使用孟德尔随机化的调查
Qi Feng1, Andrew J Grant2, Qian Yang3,4
1Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
Nutrients
|September 9, 2023
概括
这项研究发现,食用煮熟或生蔬菜与心脏病或心房动之间没有明确的联系. 生蔬菜摄入量可能会略微降低中风风险,但需要更多的研究.
科学领域:
- 营养流行病学 营养流行病学
- 心血管疾病研究研究
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明,蔬菜摄入有益于心血管健康,但随机试验的强有力的证据是有限的.
- 门德尔随机化 (MR) 为营养流行病学中的因果推理提供了一个强大的方法.
- 消费煮熟蔬菜与生蔬菜对心血管结果的明显影响在很大程度上仍未确定.
结论:
- 这项MR研究没有发现遗传预测的证据,将蔬菜消费 (煮熟或生) 与主要心血管疾病 (CHD,AF,HF) 或心脏代谢风险因素联系起来.
- 虽然生蔬菜摄入量显示出对中风风险的潜在,未经证实的益处,但蔬菜摄入量和心血管疾病预防之间的确定的因果关系需要进一步调查.
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