SLAB51多菌株益生菌配方增加了氧气处理的早产婴儿的氧化
Maria Elisabetta Baldassarre1, Massimiliano Marazzato2, Marta Pensa1
1Section of Neonatology and Neonatal Intensive Care Unit, Department of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70121 Bari, Italy.
Nutrients
|September 9, 2023
概括
一种新的益生菌,SLAB51,改善了早产婴儿患有呼吸困扰综合征 (RDS) 的氧气水平. 这种"节氧效应"可能会减少对氧疗法的需要,并增强抗氧化剂反应,提供了一个有前途的新方法.
科学领域:
- 新生儿科学 新生儿科学
- 微生物学 微生物学
- 生物化学 生物化学
背景情况:
- 过早出生的婴儿面临由于呼吸系统和抗氧化剂系统不成熟而导致缺氧和高氧的风险,增加了发病率和死亡率.
- 呼吸应急综合征 (RDS) 是早产婴儿常见的疾病,需要氧气支持.
研究的目的:
- 评估单次SLAB51益生菌剂量对改善RDS.早产婴儿氧化的疗效.
- 评估SLAB51在体外激活抗氧化反应因子Nrf2.2的能力.
主要方法:
- 一项随机对照试验,涉及使用氧气治疗RDS的早产婴儿.
- 用SLAB51益生菌或安慰剂,然后测量氧和度 (SaO2) 和SaO2/FiO2比率.
- 在体外评估暴露于SLAB51.1.的肠上皮细胞中Nrf2激活.
主要成果:
- 与安慰剂组不同的是,SLAB51组在2小时后显示出SaO2和SaO2/FiO2比率的显著增加.
- 在肠道上皮细胞中,SLAB51显著增加了Nrf2激活.
- 这项研究证实了SLAB51在早产婴儿中的节氧作用.
结论:
- 在RDS的早产婴儿中,SLAB51表现出有益的"节氧效应",改善氧化.
- SLAB51显示出增强抗氧化剂反应的潜力,可能减轻与高氧化相关的损伤.
- SLAB51为需要补充氧气的早产婴儿提供了一个有前途的治疗策略.
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