胆代谢物和胺的变化是对老年人DASH式饮食的反应
Brianna N Tate1, Gary P Van Guilder2, Marwa Aly3
1Department of Animal Science, Cornell University, Ithaca, NY 14853, USA.
Nutrients
|September 9, 2023
概括
在肥胖的老年人中,DASH饮食显著改变了血胆代谢物,增加了lysophosphatidylcholine (LPC) 和trimethylamine-N-oxide (TMAO),同时减少了phosphatidylcholine (PC) 和ceramides. 饮食影响这些脂类物种和心脏代谢健康.
科学领域:
- 营养科学 营养科学
- 代谢健康 代谢健康
- 老年学是一门学科.
背景情况:
- 老年人肥胖与不良的心脏代谢结果有关.
- 像DASH饮食这样的饮食干预措施对于管理这一群体的健康至关重要.
- 了解饮食对特定代谢物的影响是个性化营养的关键.
研究的目的:
- 调查饮食方法停止高血压 (DASH) 饮食对血胆,其代谢物和胺的影响.
- 在12周的DASH饮食干预后,评估特定脂类物种的变化,包括溶脂酸丁胆 (LPC),基米林和陶胺.
- 探索饮食诱导的代谢变化与肥胖老年人的人体/心脏代谢结果之间的关联.
主要方法:
- 一个为期12周的养试验,涉及28名肥胖的老年人.
- 参与者在标准化DASH饮食中消耗了3司或6司的牛肉.
- 胆的血含量,胆代谢物 (例如DMG,PC,LPC,TMAO),陶胺,斯芬戈米林和甘油三酸被通过血液样本量化.
主要成果:
- 达什饮食导致显著的变化:血胆 (-9.6%),二甲基甘氨酸 (DMG) (-10%),酸盐胆 (PC) (-51%),总酸盐胆 (LPC) (+281%),三甲基胺-N-氧化物 (TMAO) (+26.5%),总胺 (-22.1%),和甘油三 (-18%).
- 所有测量的LPC物种都增加了,LPC 16:0显示了最大的响应. 16:0,18:0和18: 1增加了,而24: 0减少了. 陶22:0和24:0下降,但24: 1增加.
- 胆代谢物的变化与人体测量和心脏代谢标志物相关.
结论:
- 在肥胖的老年人中,DASH饮食显著影响胆代谢.
- 饮食干预可以有效地改变LPC,斯芬哥米林和陶胺物种的循环水平.
- 这些发现凸显了饮食策略在老年人群中影响脂质代谢和心脏代谢健康的潜力.
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