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维生素D缺乏与甲状腺荷尔蒙受损的敏感性有关 甲状腺荷尔蒙受损的成年人
Liyuan Zhou1, Ying Wang2, Jingru Su1
1Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Nutrients
|September 9, 2023
概括
维生素D缺乏与成人甲状腺激素敏感性降低有关. 这项研究发现,维生素D水平低的个体表现出甲状腺激素反机制受损.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 代谢健康 代谢健康
背景情况:
- 维生素D状态和甲状腺激素调节之间的相互作用仍然不完全理解.
- 甲状腺激素的敏感性对于维持新陈代谢平衡至关重要.
- 维生素D缺乏很普遍,可能会影响各种生理过程.
研究的目的:
- 调查25-基维生素D (25(OH) D水平与成年人甲状腺激素敏感性之间的关联.
- 为了确定维生素D缺乏是否影响甲状腺激素反机制.
主要方法:
- 横截面研究包括3143名高甲状腺成年人.
- 测量血清25(OH) D,自由甲状腺素 (FT3),自由甲状腺素 (FT4),甲状腺刺激激素 (TSH) 和其他代谢标记物.
- 甲状腺激素敏感度指数的计算,包括TFQI,PTFQI,TSHI和TT4RI.
主要成果:
- 在58.8%的参与者中,存在维生素D缺乏 (25(OH) D <20 ng/mL).
- 维生素D缺乏的人表现出显著更高的甘油三,胰岛素,FT3,FT4,TSH和甲状腺激素敏感度指数 (TFQI,PTFQI,TSHI,TT4RI).
- 后勤回归显示,维生素D缺乏与甲状腺激素敏感性受损的风险显著增加有关 (ORs从1.50到1.70不等).
结论:
- 维生素D缺乏与成人无甲状腺激素对甲状腺激素的敏感性受损显著相关.
- 这些发现表明维生素D在甲状腺激素代谢和作用中可能发挥作用.
- 需要进一步的研究来探索临床影响和潜在的干预措施.
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