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发酵的甜菜改善了与小鼠肠道微生物群变化相关的酒精中毒症状

Qingmiao Ma¹, Masafumi Noda¹, Narandalai Danshiitsoodol¹

¹Department of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-ku, Hiroshima 734-8551, Japan.

|September 9, 2023

概括

用乳酸细菌 (LAB) 发酵的牛提取物改善了以乙醇养小鼠的肠道微生物群. 这种干预降低了肝酶和三甲基胺 (TMA) 水平,恢复了微生物平衡.

科学领域:

微生物学微生物学
胃肠病学胃肠病学
草药是一种草药.

背景情况:

持续的乙醇消费会诱导肠道失调,并改变肠道微生物群.
参与肠道炎症的特定细菌系受到乙醇摄入的影响.
三甲基胺 (TMA) 的生产力可以作为肠道失调的潜在指标.

研究的目的:

为了研究发酵的甜提取物与Pediococcus pentosaceus LY45对小鼠以乙醇诱导的肠道失生症的影响.
评估发酵提取物对肝酶和TMA生产力的影响.
为了分析 cecal 微生物群组成的变化.

主要方法:

将发酵的菜提取物 (Pediococcus pentosaceus LY45) 给以乙醇养的小鼠使用.
测量血清中阿斯巴酸氨基转移酶 (AST) 和氨基转移酶 (ALT) 的水平.
评估TMA的生产力在Cecal内容.
微生物群分析,以确定细菌群的变化.

主要成果:

发酵的菜提取物显著降低了以乙醇养小鼠的升高的AST和ALT水平.
由于发酵的菜提取物减少了TMA的产量.
促炎性细菌属 (SMB53,Dorea) 的变化恢复到正常水平.
提取物减轻了乙醇诱导的肠道失调.

结论:

使用乳酸细菌 (LABs) 发酵的牛提取物显示出改善乙醇诱导的肠道失调的潜力.
通过发酵生物转化草药前体提供了一个有前途的策略,可以生产可以重建肠道微生物群的代谢物.
这种方法可能会导致肠道健康的新型治疗干预.

关键词:

这种疾病叫做dysbiosis.我们的肠道微生物群.乳酸细菌是一种乳酸细菌.药用草药药用草药药用草药史蒂维亚史蒂维亚是一个

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