多糖:代谢相关脂肪肝疾病 (MAFLD) 的潜在益生菌
1Tianjin Key Laboratory of Digestive Diseases, Department of Gastroenterology and Hepatology, Tianjin Institute of Digestive Diseases, National Key Clinical Specialty, General Hospital, Tianjin Medical University, Tianjin 300052, China.
Nutrients
|September 9, 2023
概括
来自真菌和藻类的饮食多糖化物,在对抗代谢功能障碍相关的脂肪肝疾病 (MAFLD) 中表现有前途. 这些化合物充当益生菌,改善肠道健康,并可能提供新的MAFLD治疗方法.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是导致慢性肝病的全球主要原因.
- 驱动MAFLD病原体的确切机制尚未完全理解.
- 肠肝轴因其在MAFLD发展中的作用越来越被认可.
研究的目的:
- 审查饮食中的多糖对MAFLD的保护作用.
- 探索多糖与肠道微生物群及其代谢物相互作用的机制.
- 突出基于多糖生物活性的MAFLD潜在的治疗策略.
主要方法:
- 这是对现有研究进行综合的叙述性综述.
- 专注于研究从真菌和藻类来源的多糖化物.
- 检查了多糖类对肠道微生物组调节,肠道屏障功能和微生物代谢物的影响.
主要成果:
- 多糖对糖代谢,脂质代谢,炎症和氧化应激产生有益影响.
- 它们的益生菌性质调节肠道微生物群的组成和功能.
- 多糖调节关键的微生物代谢物,包括脂多糖 (LPS),短链脂肪酸 (SCFA) 和胆汁酸 (BA).
结论:
- 多糖体在预防和治疗MAFLD方面具有显著的潜力.
- 它们与肠道微生物群及其代谢物的相互作用对于它们的保护作用至关重要.
- 对多糖生物活性分子机制的进一步研究可能会产生新的MAFLD治疗途径.
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