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维生素D缺乏对神经内分泌新生体瘤侵略性的影响
Manuela Albertelli1,2, Cristian Petolicchio1, Sara Brasili1
1Endocrinology Unit, Department of Internal Medicine and Medical Specialties (DiMI), University of Genova, 16132 Genoa, Italy.
Nutrients
|September 9, 2023
概括
维生素D缺乏在神经内分泌新生瘤 (NENs) 中很常见,并且与瘤攻击性增加有关. 对NEN患者来说,监测维生素D (25(OH) D水平至关重要,因为它与更高的ki67和疾病进展有关.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 营养科学 营养科学
背景情况:
- 维生素D (25(OH) D) 在各种疾病中起着已知的作用,包括自身免疫性疾病,糖尿病和癌症.
- 维生素D缺乏对神经内分泌瘤 (NENs) 的具体影响需要进一步研究.
研究的目的:
- 为了确定与健康对照组相比,NEN患者中维生素D缺乏的患病率.
- 评估维生素D (25(OH) D作为NENs的预后因素,评估其与瘤侵略性,进展和生存的关联.
主要方法:
- 研究了172名神经内分泌瘤 (NEN) 患者的队列 (2009-2023年).
- 测量了血清25(OH) D水平,缺陷定义为≤20 ng/mL.
- 分析了25...OH) D水平与NEN分级,分阶段,ki67指数,总生存 (OS) 和无进展生存 (PFS) 之间的关联.
主要成果:
- 与对照组相比,NEN患者的血清25(OH) D水平明显低于对照组 (p < 0.001).
- 维生素D缺乏 (25(OH) D <20 ng/mL) 与较高的ki67指数 (p = 0.02) 和疾病进展的增加 (p = 0.02) 相相关.
- 没有观察到25(OH) D水平对PFS或OS的显著影响.
结论:
- 维生素D缺乏症在神经内分泌瘤 (NEN) 患者中非常普遍.
- 维生素D水平较低与预后较差的指标有关,包括较高的ki67和疾病进展.
- 建议在NEN患者中监测25(OH) D水平,因为它与瘤的攻击性有关.
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