心理压力和铁状况对早期神经发育结果的相互作用
Brie M Reid1,2, Michael K Georgieff3
1Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.
Nutrients
|September 9, 2023
概括
缺铁状况和心理困扰显著影响婴儿神经发育. 了解它们的综合作用对于早期干预和长期认知健康至关重要.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 营养科学 营养科学
背景情况:
- 缺铁和心理压力是常见的,在怀孕和生命早期经常同时发生.
- 这两个因素独立地影响神经认知发育,但它们的综合影响还没有得到充分研究.
- 早期的生活压力和铁缺乏对认知功能有长期影响.
研究的目的:
- 审查有关心理压力和早期发育中的铁状况的证据.
- 探索连接压力,铁代谢和神经认知的假设机制.
- 突出需要研究压力和缺铁对儿童发育的综合影响.
主要方法:
- 动物和人类研究的叙述性综述.
- 审查关于心理压力和铁状况的研究.
- 对神经认知发育的重叠影响的分析.
主要成果:
- 心理压力激活HPA轴并增加促炎性细胞因子,可能通过肝激素破坏铁代谢.
- 有证据表明,压力,改变铁的状态和神经发育的改变之间存在联系.
- 产前压力和铁缺乏对长期认知的联合影响需要进一步研究.
结论:
- 研究心理压力对铁代谢的影响对于理解高危儿童神经认知发育至关重要.
- 铁可能会调解早期压力和后代神经发育之间的关系.
- 未来的研究应该专注于针对性干预的双重暴露研究.
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