在以纳米材料为基础的平台上对合成甲基的法医分析:化学辅助的电压测量和UPLC-MS/MS调查
Ana-Maria Dragan1,2, Bogdan George Feier1, Mihaela Tertiș1
1Department of Analytical Chemistry, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, Pasteur 6, 400349 Cluj-Napoca, Romania.
Nanomaterials (Basel, Switzerland)
|September 9, 2023
概括
一种新的电化学方法可以快速检测到合成甲基 (SCs),也称为"合法高". 这种快速选测试有助于执法部门在没收样本中识别这些新兴的精神活性物质.
科学领域:
- 分析化学 分析化学
- 电化学 电化学 电化学
- 法医科学 法医科学 法医科学
背景情况:
- 合成甲基 (SCs) 是新兴的精神活性物质,经常被执法部门遇到.
- 新的SC化合物的不断出现需要快速选方法来识别.
- 现有的检测方法可能缺乏分散查所需的速度和可访问性.
研究的目的:
- 开发一种快速,简单和分散的方法来检测四种特定的合成甲基.
- 使用电化学资料来识别和量化SCs.
- 为了验证该方法在现实世界被没收的样本上的性能.
主要方法:
- 使用循环和正方形波电压测量进行电压测量表征.
- 通过液体色谱学与质谱学相结合,解氧化还原通路.
- 化学测量数据处理以优化电化学平台和电解质pH值.
- 使用标准解决方案和实际没收样本进行方法验证.
主要成果:
- 为检测α-pyrrolidinovalerophenone,N-ethylhexedrone,4-chloroethcathinone和3-chloromethcathinone而开发了一种强大的电化学方法.
- 优化的方法证明了广泛的线性范围和低检测极限 (LODs),适合选.
- 在真实样本上的验证显示性能与便携式拉曼光谱仪相当.
结论:
- 开发的电化学方法为分散的SC检测提供了快速简单的方法.
- 这种方法为执法机构提供了一种有价值的工具,用于选被没收的物质.
- 该技术显示出作为法医分析的便携式和有效替代方案的前景.
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