来自Allii Macrostemonis Bulbus的两种新化合物及其体外抗氧化活性
Jianfa Wu1, Lei Li1, Chang Liu1
1Department of Traditional Chinese Medicine, College of Traditional Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Molecules (Basel, Switzerland)
|September 9, 2023
概括
从Allii Macrostemonis Bulbus中分离出了两种新的化合物和十种已知的化合物. 几种化合物表现出显著的抗氧化活性,有可能发现新的天然抗氧化剂.
科学领域:
- 植物化学 植物化学
- 自然产品 化学 化学
- 药理学是指药理学,即药理学是指药理学.
背景情况:
- 艾利·马克罗斯特莫尼斯·布尔布斯 (Allii Macrostemonis Bulbus) 是一种传统的药用植物.
- 研究其化学成分可以揭示新的生物活性化合物.
- 了解植物化学特征有助于质量控制和药物发现.
研究的目的:
- 从Allii Macrostemonis Bulbus中分离和描述新的和已知的化合物.
- 评估分离化合物的抗氧化活性.
- 识别潜在的质量标志物和新型天然抗氧化剂.
主要方法:
- 使用80%的乙醇和n-butanol进行提取.
- 使用HR-ESI-MS,1D和2DNMR光谱学的结构阐明.
- 抗氧化活性测定包括铁离子还原,超氧化离子激素清理,DPPH和ABTS测定.
主要成果:
- 确定了两个新的化合物,4,4'-bis(β-D-glucopyranosyloxy) 双 (1) 和一个复杂的螺旋醇糖化物 (2).
- 还分离了10种已知的化合物,包括一种黄类糖化物 (3),类固醇 (4-10),一种核糖化物 (11),一种类糖化物 (12),等.
- 化合物1,2和3表现出显著的抗氧化活性,其中化合物1显示出强大的铁离子还原,而化合物2和3表现出强烈的超氧化离子激素清理. 化合物3也显示出大量的DPPH和ABTS激素清除活动.
结论:
- 新化合物1和2的分离有助于对Allii Macrostemonis Bulbus的植物化学知识.
- 已识别的化合物,特别是1,2和3,具有显著的抗氧化特性.
- 这些发现表明Allii Macrostemonis Bulbus在开发天然抗氧化剂和建立质量控制标志物的潜在应用.
相关概念视频
02:44Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
Alkenes are converted to 1,2-diols or glycols through a process called dihydroxylation. It involves the addition of two hydroxyl groups across the double bond with two different stereochemical approaches, namely anti and syn. Dihydroxylation using osmium tetroxide progresses with syn stereochemistry.
02:21Oxidation of Alkenes: Syn Dihydroxylation with Potassium Permanganate
Alkenes can be dihydroxylated using potassium permanganate. The method encompasses the reaction of an alkene with a cold, dilute solution of potassium permanganate under basic conditions to form a cis-diol along with a brown precipitate of manganese dioxide.
02:04Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids
Diols are compounds with two hydroxyl groups. In addition to syn dihydroxylation, diols can also be synthesized through the process of anti dihydroxylation. The process involves treating an alkene with a peroxycarboxylic acid to form an epoxide. Epoxides are highly strained three-membered rings with oxygen and two carbons occupying the corners of an equilateral triangle. This step is followed by ring-opening of the epoxide in the presence of an aqueous acid to give a trans diol.
01:46Oxidative Cleavage of Alkenes: Ozonolysis
In ozonolysis, ozone is used to cleave a carbon–carbon double bond to form aldehydes and ketones, or carboxylic acids, depending on the work-up.
Ozone is a symmetrical bent molecule stabilized by a resonance structure.
Ozone is a symmetrical bent molecule stabilized by a resonance structure.
01:20Radical Autoxidation
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
01:21Radical Oxidation of Allylic and Benzylic Alcohols
Activated manganese(IV) oxide can selectively oxidize allylic and benzylic alcohols via a radical intermediate mechanism. Primary allylic alcohols are oxidized to aldehydes, while secondary allylic alcohols yield ketones. The redox reaction of potassium permanganate with an Mn(II) salt such as manganese sulfate (under either alkaline or acidic conditions), followed by thorough drying, yields the oxidizing agent: activated MnO2. While MnO2 is insoluble in the solvents used for the reaction, the...