深海真菌Trichoderma lixii R22中的脂类和类及其与两种小麦病原体的对抗性
Chang-Peng Li1,2, Zhen-Zhen Shi1, Sheng-Tao Fang1
1Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
Molecules (Basel, Switzerland)
|September 9, 2023
概括
海洋真菌Trichoderma lixii产生了五种新的脂质,三素A-E和两个已知的类. 这些化合物对小麦病原体具有抗真菌活性,对盐水有低毒性.
科学领域:
- 海洋天然产品化学 海洋天然产品化学
- 的二次代谢产物 的二次代谢产物
- 发现抗微生物药物发现.
背景情况:
- 深海有各种微生物,它们有可能产生新的生物活性化合物.
- 海洋衍生真菌,特别是来自Trichoderma属的真菌,是独特化学结构的有希望的来源.
研究的目的:
- 从深海Trichoderma lixii菌株中分离和描述新的生物活性化合物.
- 评估分离化合物的抗真菌活性和毒性.
主要方法:
- 使用色谱技术分离和净化化合物.
- 通过全面的光谱分析 (MS,IR,NMR) 阐明结构.
- 使用二molybdenum诱导的电子圆二极化 (ECD) 数据来确定绝对配置.
主要成果:
- 确定了五种新的脂质 (三素A-E) 和两种已知的类 (巴西兰A和哈尔齐安A).
- 三素A和B对Fusarium graminearum (MIC = 25.0μg/mL) 具有抗真菌活性.
- 布拉西兰A证明了对Gaeumannomyces graminis (MIC = 12.5μg/mL) 的抑制作用.
- 所有测试的化合物对盐酸菌具有低毒性.
结论:
- 这项研究扩大了已知的海洋衍生Trichoderma代谢物的化学多样性.
- 三素A-E和巴西兰A代表了具有潜在农业应用的新型化学实体,作为杀菌剂.
- 低毒性概况表明,潜在开发的安全边际有利.
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