作为抗生素来源的芬华山的药用植物内生菌微生物
Aiping Yang1, Yu Hong1,2, Fengjuan Zhou1
1College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Molecules (Basel, Switzerland)
|September 9, 2023
概括
研究人员从药用植物中的内菌中发现了新的抗生素化合物. 这些天然产品显示出对抗抗生素耐药性和治疗真菌感染的潜力.
科学领域:
- 微生物学 微生物学
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗生素耐药性是全球主要的健康威胁,需要发现新型抗菌剂.
- 微生物,特别是植物内存在的内微生物,是识别新疗法化合物的有希望的来源.
研究的目的:
- 为了探索来自药用植物的内菌微生物,在中国的黄山,为了新型抗生素的发现.
- 从具有潜在抗微生物活性的选择性内菌株中分离和描述二次代谢物.
主要方法:
- 从九种药用植物物种中分离和分类识别了269个内菌株.
- 扩大有前途的菌株的发酵,然后使用LC-MS进行代谢分析.
- 使用MS和NMR光谱学,以抗菌活性为导向的二次代谢物的隔离和结构阐明.
主要成果:
- 隔离了23种二次代谢产物,其中包括一种新型索比西林类似物.
- 昆明氨酸A对细菌 (黄金色,B. subtilis,大肠杆菌,A. baumannii) 和真菌 (A. fumigatus,C. neoformans) 显示出强大的广泛活性.
- 其他几个化合物,包括sorrentanone和emodic acid,表现出不同程度的抗菌活性.
结论:
- 来自黄山药用植物的内菌微生物代表了发现新抗生素的宝贵资源.
- 已识别的二次代谢产物,特别是昆明A,显示出作为抗微生物和抗真菌剂的开发潜力很大.
- 这项研究强调了对新型天然产品的内性动因细菌生物勘探的重要性,以应对抗微生物耐药性的挑战.
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