的氧化 (II) 抗癌剂[Pt{(p-BrC6F4) NCH2CH2NEt2}Clpy) 到的氧化 (IV) 复合物通过过氧化
Ruchika Ojha1, Peter C Junk2, Alan M Bond1
1School of Chemistry, Monash University, Clayton, VIC 3800, Australia.
Molecules (Basel, Switzerland)
|September 9, 2023
概括
(IV) 复合物被合成为潜在的抗癌前药物. (II) 剂与过氧化的氧化产生 (IV) 复合物,这些复合物可以恢复到 (II) 形式.
科学领域:
- 无机化学 无机化学 有机化学
- 药用化学 医学化学
- 材料科学 材料科学 材料科学
背景情况:
- (IV) 协调复合物作为 (II) 抗癌药物具有优势,因为它们具有固有的稳定性.
- 由于Pt(IV) 复合物的惰性性质,可以绕过Pt(II) 剂常见的失活路径.
研究的目的:
- 报告从 (II) 抗瘤剂中获得的新 (IV) 复合物的合成和特征.
- 用过氧化研究Pt(II) 复合物的氧化到Pt(IV) 并优化反应条件以获得更高的产量.
主要方法:
- 在室温下使用过氧化 (H2O2) 氧化 (II) 抗瘤剂[Pt (II) (p-BrC6F4) NCH2CH2NEt2}Cl (py) ] (1) .
- 通过使用化作为添加剂和二甲中Pt:H2O2的1:2比率来优化产量.
- 使用单晶X射线衍射和X射线粉碎衍射,对产生的 (IV) 复合物 (2·H和3·0.5CH) 的结构性表征.
- 在固态和溶液中的Pt(IV) 到Pt(II) 复合物的还原性脱水的分析,使用X射线粉末衍射,1H和19FNMR光谱学和质谱学.
主要成果:
- 在室温下使用H2O2成功将Pt (II) 复合物1氧化为二氧化 (IV) 溶盐复合物 (2·H),使用LiCl和1:2 Pt:H2O2比率获得最佳产量.
- 获得了2·H复合物的两种形式 (金色和红色),两者都具有相同的八面体结构,具有特定的连接体排列.
- 另一种溶解物3·0.5CH被合成,使用四甲基化物作为化物来源.
- 合成的Pt(IV) 复合物经历了在固体和溶液状态下随着时间的推移减少脱水到Pt(II) 复合物 (1H).
- 在过多的H2O2和高温条件下有利于联体氧化,而金属氧化到Pt (IV) 则有利于在室温下控制量的H2O2.
结论:
- 在室温下对 (II) 复合物与过氧化进行控制的氧化,为 (IV) 预制药提供了可行的途径.
- 该研究表明了新型Pt(IV) 复合物的结构特征和反应性,突出了它们作为抗癌剂的潜力.
- 反应条件,特别是H2O2的数量和温度,对氧化过程的结果产生了关键的影响,有利于金属或连接体的氧化.
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