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提高SiCN涂层表面的疏水性和抗菌性质,并进行四级化处理,以解决围植入炎问题
Chao-Ching Chiang1, Xinyi Xia1, Valentin Craciun2
1Department of Chemical Engineering, College of Engineering, University of Florida, Gainesville, FL 32611, USA.
Materials (Basel, Switzerland)
|September 9, 2023
概括
新开发的用于牙科植入物的碳化 (SiCN) 涂层显示出显著的抗菌特性. 四元化SiCN表面减少了Streptococcus mutans的80%,提供了一种对围部植入炎的有希望的解决方案.
科学领域:
- 生物材料科学 生物材料科学
- 牙科植入物学 牙科植入物学
- 微生物学 微生物学
背景情况:
- 牙周植入物炎是导致牙植入物失败的主要原因,主要是由细菌感染引起的.
- 传统的植入物缺乏固有的抗菌特性,需要新的解决方案.
- 碳化 (SiCN) 涂层对牙科植入物具有潜在的优势,但其抗菌功效需要评估.
研究的目的:
- 评估碳化物 (SiCN) 涂层在牙科植入物上的抗菌潜力.
- 通过四化来修改SiCN表面,传递正电荷以抑制细菌粘附.
- 评估修改后的SiCN对Streptococcus mutans (S. mutans) 感染的疗效.
主要方法:
- 通过四级化对SiCN涂层的表面修改,以创建带正电荷的原子.
- 使用接触角测量和X射线光电子谱学 (XPS) 进行表面化学变化的表征.
- 用S. mutans对修改的SiCN和控制表面进行注射,然后进行细菌殖民地计数,光显微镜和扫描电子显微镜 (SEM).
主要成果:
- 与控制表面相比,四化SiCN表面显示培养细菌殖民地减少了80%.
- 光显微镜显示,在化3天和7天后,修改后的SiCN表面上的细菌覆盖率显著减少.
- SEM分析证实了抗菌机制,显示四分化SiCN表面上的细菌膜破裂.
结论:
- 四元化SiCN涂层对S. mutans表现出强大的抗菌活性.
- 通过四级化对SiCN的表面修饰是一种有效的策略,可以增强其用于牙科植入物的抗菌性质.
- 这些发现表明,四分化SiCN涂层有望预防植入周炎并提高牙植入成功率.
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